ホームIMICライブラリMMWR抄訳2020年(Vol.69)破傷風トキソイド、弱毒化ジフテリアトキソイド、無細・・・
MMWR抄訳
2020/01/24Vol. 69 / No. 3
MMWR69(3):77-83
Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2019
破傷風トキソイド、弱毒化ジフテリアトキソイド、無細胞性百日咳ワクチンの使用:最新のAdvisory Committee on Immunization Practicesの推奨事項 ― アメリカ、2019年
2005年以降、思春期および成人を対象に破傷風トキソイド/弱毒化ジフテリアトキソイド/無細胞性百日咳(Tdap)ワクチンの単回投与が、Advisory Committee on Immunization Practices(ACIP)によって推奨されている。Tdapの接種後、破傷風/ジフテリアトキソイド(Td)ワクチンのブースター接種は、10年ごと、または創傷治療で適応となる場合に推奨されている。以前はTdのみが推奨されていたが、2019年10月のACIP会議にてTdまたはTdapの使用を許可することを推奨事項として更新した。一般的な推奨事項として、11~18歳ではTdapを単回接種すべきであり、11~12歳の予防的ケア受診時が望ましい。19歳以上でTdapを接種したことがない人では、破傷風またはジフテリアトキソイド含有するワクチンの最終接種時からの間隔に関係なく、Tdap接種を単回接種すべきである。また、破傷風とジフテリアに対する予防を持続させるために、生涯にわたり10年ごとにTdまたはTdapをブースター接種すべきである。妊婦のTdap定期予防接種に関する推奨事項に変更はない。破傷風トキソイド含有ワクチンは、同ワクチンの最終接種から5年以上が経過した場合の創傷治療に適応となる。破傷風トキソイド含有ワクチンを11歳以上に適応する場合、Tdap未接種またはTdapの接種歴が不明な人にはTdapが望ましい。妊婦に破傷風トキソイド含有ワクチンを適応する場合、Tdapを使用するべきである。過去にTdapワクチン接種歴がある非妊娠女性では、TdまたはTdapを使用可能である。キャッチアップ接種として、7~18歳および19歳以上では、百日咳、破傷風、ジフテリアの予防接種歴がない場合、少なくとも1回のTdapの接種を含む3回の破傷風/ジフテリアトキソイド含有ワクチンを接種するべきである。小児期の予防接種スケジュールを完遂し、最後のワクチン接種が10年より前の妊婦では、新生児の破傷風予防のために、破傷風トキソイド含有ワクチンのブースター接種をすべきである。年齢および妊娠状態に基づくオフラベル使用に変更はなく、禁忌と予防措置は以前の推奨事項から変更されていない。
References
- Broder KR, Cortese MM, Iskander JK, et al.; Advisory Committee on Immunization Practices (ACIP). Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006;55(No. RR-3).
- Kretsinger K, Broder KR, Cortese MM, et al.; Advisory Committee on Immunization Practices; Healthcare Infection Control Practices Advisory Committee. Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel. MMWR Recomm Rep 2006;55(No. RR-17).
- Liang JL, Tiwari T, Moro P, et al. Prevention of pertussis, tetanus, and diphtheria with vaccines in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2018;67(No. RR-2). <https://doi.org/10.15585/mmwr.rr6702a1>
- CDC. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine in adults aged 65 years and older—Advisory Committee on Immunization Practices (ACIP), 2012. MMWR Morb Mortal Wkly Rep 2012;61:468–70.
- CDC. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women—Advisory Committee on Immunization Practices (ACIP), 2012. MMWR Morb Mortal Wkly Rep 2013;62:131–5.
- Beytout J, Launay O, Guiso N, et al. Safety of Tdap-IPV given one month after Td-IPV booster in healthy young adults: a placebo-controlled trial. Hum Vaccin 2009;5:315–21. <https://doi.org/10.4161/hv.5.5.6911>
- Talbot EA, Brown KH, Kirkland KB, Baughman AL, Halperin SA, Broder KR. The safety of immunizing with tetanus-diphtheria-acellular pertussis vaccine (Tdap) less than 2 years following previous tetanus vaccination: experience during a mass vaccination campaign of healthcare personnel during a respiratory illness outbreak. Vaccine 2010;28:8001–7. <https://doi.org/10.1016/j.vaccine.2010.09.034>
- Halperin SA, McNeil S, Langley J, et al. Tolerability and antibody response in adolescents and adults revaccinated with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine adsorbed (Tdap) 4-5 years after a previous dose. Vaccine 2011;29:8459–65. <https://doi.org/10.1016/j.vaccine.2011.07.068>
- Knuf M, Vetter V, Celzo F, Ramakrishnan G, Van Der Meeren O, Jacquet JM. Repeated administration of a reduced-antigen-content diphtheria-tetanus-acellular pertussis and poliomyelitis vaccine (dTpa- IPV; Boostrix™ IPV). Hum Vaccin 2010;6:554–61. <https://doi.org/10.4161/hv.6.7.11760>
- Booy R, Van der Meeren O, Ng SP, Celzo F, Ramakrishnan G, Jacquet JM. A decennial booster dose of reduced antigen content diphtheria, tetanus, acellular pertussis vaccine (Boostrix™) is immunogenic and well tolerated in adults. Vaccine 2010;29:45–50. <https://doi.org/10.1016/j.vaccine.2010.10.025>
- Halperin SA, Scheifele D, De Serres G, et al. Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose. Vaccine 2012;30:974–82. <https://doi.org/10.1016/j.vaccine.2011.11.035>
- Mertsola J, Van Der Meeren O, He Q, et al. Decennial administration of a reduced antigen content diphtheria and tetanus toxoids and acellular pertussis vaccine in young adults. Clin Infect Dis 2010;51:656–62. <https://doi.org/10.1086/655825>
- Advani A, Hallander HO, Dalby T, et al. Pulsed-field gel electrophoresis analysis of Bordetella pertussis isolates circulating in Europe from 1998 to 2009. J Clin Microbiol 2013;51:422–8. <https://doi.org/10.1128/JCM.02036-12>
- Weston W, Messier M, Friedland LR, Wu X, Howe B. Persistence of antibodies 3 years after booster vaccination of adults with combined acellular pertussis, diphtheria and tetanus toxoids vaccine. Vaccine 2011;29:8483–6. <https://doi.org/10.1016/j.vaccine.2011.09.063>
- Tomovici A, Barreto L, Zickler P, et al. Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine. Vaccine 2012;30:2647–53. <https://doi.org/10.1016/j.vaccine.2012.02.013>
- Barreto L, Guasparini R, Meekison W, Noya F, Young L, Mills E. Humoral immunity 5 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine. Vaccine 2007;25:8172–9. <https://doi.org/10.1016/j.vaccine.2007.09.031>
- Edelman KJ, He Q, Makinen JP, et al. Pertussis-specific cell-mediated and humoral immunity in adolescents 3 years after booster immunization with acellular pertussis vaccine. Clin Infect Dis 2004;39:179–85. <https://doi.org/10.1086/421943>
- McIntyre PB, Turnbull FM, Egan AM, Burgess MA, Wolter JM, Schuerman LM. High levels of antibody in adults three years after vaccination with a reduced antigen content diphtheria-tetanus-acellular pertussis vaccine. Vaccine 2004;23:380–5. <https://doi.org/10.1016/j.vaccine.2004.05.030>
- Edelman K, He Q, Mäkinen J, et al. Immunity to pertussis 5 years after booster immunization during adolescence. Clin Infect Dis 2007;44:1271–7. <https://doi.org/10.1086/514338>
- McIntyre PB, Burgess MA, Egan A, Schuerman L, Hoet B. Booster vaccination of adults with reduced-antigen-content diphtheria, tetanus and pertussis vaccine: immunogenicity 5 years post-vaccination. Vaccine 2009;27:1062–6. <https://doi.org/10.1016/j.vaccine.2008.11.102>
- Acosta AM, DeBolt C, Tasslimi A, et al. Tdap vaccine effectiveness in adolescents during the 2012 Washington State pertussis epidemic. Pediatrics 2015;135:981–9. <https://doi.org/10.1542/peds.2014-3358>
- Klein NP, Bartlett J, Fireman B, Baxter R. Waning Tdap effectiveness in adolescents. Pediatrics 2016;137:e20153326. <https://doi.org/10.1542/peds.2015-3326>
- Koepke R, Eickhoff JC, Ayele RA, et al. Estimating the effectiveness of tetanus-diphtheria-acellular pertussis vaccine (Tdap) for preventing pertussis: evidence of rapidly waning immunity and difference in effectiveness by Tdap brand. J Infect Dis 2014;210:942–53. <https://doi.org/10.1093/infdis/jiu322>
- Kamiya H, Cho BH, Messonnier ML, Clark TA, Liang JL. Impact and cost-effectiveness of a second tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine dose to prevent pertussis in the United States. Vaccine 2016;34:1832–8. <https://doi.org/10.1016/j.vaccine.2016.02.027>
- Goebel EM, Zhang X, Harvill ET. Bordetella pertussis infection or vaccination substantially protects mice against B. bronchiseptica infection. PLoS One 2009;4:e6778. <https://doi.org/10.1371/journal.pone.0006778>
- Warfel JM, Zimmerman LI, Merkel TJ. Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model. Proc Natl Acad Sci U S A 2014;111:787–92. <https://doi.org/10.1073/pnas.1314688110>
- CDC. Advisory Committee on Immunization Practices summary report. Atlanta, GA. US Department of Health and Human Services, CDC; 2013. <https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-jun13.pdf>
- Food and Drug Administration. Full prescribing information [package insert]: Adacel. Silver Spring, MD: US Department of Health and Human Services, Food and Drug Administration; 2019. <https://www.fda.gov/media/119862/download>
- Jackson ML, Yu O, Nelson JC, et al. Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents. Pharmacoepidemiol Drug Saf 2018;27:921–5. <https://doi.org/10.1002/pds.4569>
- Halperin SA, Donovan C, Marshall GS, et al.; Tdap Booster Investigators. Randomized controlled trial of the safety and immunogenicity of revaccination with tetanus-diphtheria-acellular pertussis vaccine (Tdap) in adults 10 years after a previous dose. J Pediatric Infect Dis Soc 2019;8:105–14. <https://doi.org/10.1093/jpids/pix113>
- Kovac M, Kostanyan L, Mesaros N, Kuriyakose S, Varman M. Immunogenicity and safety of a second booster dose of an acellular pertussis vaccine combined with reduced antigen content diphtheria-tetanus toxoids 10 years after a first booster in adolescence: an open, phase III, non-randomized, multi-center study. Hum Vaccin Immunother 2018;14:1977–86. <https://doi.org/10.1080/21645515.2018.1460292>
- Brandon D, Kimmel M, Kuriyakose SO, Kostanyan L, Mesaros N. Antibody persistence and safety and immunogenicity of a second booster dose nine years after a first booster vaccination with a reduced antigen diphtheria-tetanus-acellular pertussis vaccine (Tdap) in adults. Vaccine 2018;36:6325–33. <https://doi.org/10.1016/j.vaccine.2018.08.051>
- Theeten H, Rümke H, Hoppener FJ, et al. Primary vaccination of adults with reduced antigen-content diphtheria-tetanus-acellular pertussis or dTpa-inactivated poliovirus vaccines compared to diphtheria-tetanus-toxoid vaccines. Curr Med Res Opin 2007;23:2729–39. <https://doi.org/10.1185/03007X233034>
- Shimabukuro TT, Nguyen M, Martin D, DeStefano F. Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS). Vaccine 2015;33:4398–405. <https://doi.org/10.1016/j.vaccine.2015.07.035>
- Fortner KB, Swamy GK, Broder KR, et al. Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women. Vaccine 2018;36:6354–60. <https://doi.org/10.1016/j.vaccine.2018.07.012>
- Sukumaran L, McCarthy NL, Kharbanda EO, et al. Association of Tdap vaccination with acute events and adverse birth outcomes among pregnant women with prior tetanus-containing immunizations. JAMA 2015;314:1581–7. <https://doi.org/10.1001/jama.2015.12790>
- National Center for Immunization and Respiratory Diseases. Vaccine price list. Atlanta, GA; US Department of Human Services, CDC, National Center for Immunization and Respiratory Diseases; 2018. <https://www.cdc.gov/vaccines/programs/vfc/awardees/vaccine-management/price-list/index.html>
- Havers FP, Cho BH, Walker JW, Hariri S. Economic impact of implementing decennial tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccination in adults in the United States. Vaccine 2020;38:380–7. <https://doi.org/10.1016/j.vaccine.2019.09.104>
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